Roller Bottle Systems
Quicker. Easier. Safer. Better.
Meet the revolutionary RC-40. Once its bottle packs are installed, everything from media exchange to harvesting can be done automatically in a self-contained environment. This saves time and labor costs while optimizing yields and virtually eliminating contamination.Inquire About
The RC-40 System Download
Introducing the superior RC-40 (Mark 2)
The RC-40 has two 20-bottle position rotors, each fitted with a multichannel peristaltic pump. Pump volume, rotor direction (both clock and counter clock wise) and speed are controlled via a simple programmable CPU.
CONSISTENT PRESSURE APPLICATION
Homogeneous flling is achieved because colinear axis points allow for consistent pressure to be applied on each tube. This results in pump flling accuracy of +/-5%.
AUTOMATIC TILT SYSTEM
Frame + Rotors
Signifcant improvements to the traditional roller apparatus allows for automation of all tasks previously undertaken manually or by robotic processors
Modern Siemens HMI KPP 400 Comfort controls include password protection, alarm histories, remote operation and multi-language capabilities
Time to convert from labscale to RC-40 commercial manufacturing
Rc-40 Roller Bottle System
CLOSED AUTOMATED PROCESSING
Unlike robots or traditonal roller bottle handling systems, the RC-40 automates all stages of a rollter bottle process. For example the RC-40 can perform a media exchange of all 40 bottles (in one frame) simultaneously and without opening them.
One RC-40 system enables a single operator to complete a full roller bottle tissue culture protocol - seeding, media change, trypsinisation and harvest.
Time for operator to perform media exchange of 40 5x roller bottles without opening them
The gamma-irradiated RC-40 Bottle Packs consist of 20 bottles ready-assembled with tubings, manifolds, and filters providing access to the cell culture area via a single aseptic connection. One Bottle Pack is required per rotor and once placed in the rotor, RC-40 Bottle Packs enable all further processing to be performed without additional bottle handling by the system operator. These unique Bottle Packs provide a closed production environment, virtually eliminating handling related contaminations.
Guide and spring concept assures easy initial bottle load, and unload upon processing completion, by operator.
20 BOTTLE READY-ASSEMBLED PACKS
PETG and polystyrene bottle formats come in Flat Wall or Expanded Surface providing a range of culture area/pack*. *Flat Wall: +/- 36,000 cm² Extended Surface: +/- 84,000 cm².
SINGLE ASEPTIC CONNECTION
Tubings, manifolds, and flters provide access of up to 84,000 cm² of cell culture area via one aseptic connector.
Time for operator to harvest 40 5x roller bottles without opening them
User-friendly. Affordable. Saves time. Saves labor costs
MANUAL OR ROBOTIC SYSTEM OPERATON VS. RC-40 AUTOMATED SYSTEM
PRODUCTION PROTOCOL Comparison
Comparing the time taken to process the equivalent of 200 standard bottles manually or with a robotic automated system versus the RC-40 shows the major positive impact on labor cost and total cost of production.
Simple (Cell Harvest) culture protocol
Multi-harvest (10x harvest/refeed) protocol
USED IN RESEARCH LABORATORIES & LARGE SCALE MANUFACTURING SITES
RC-40 BOTTLE SYSTEM
Roller bottles offer an established, reliable method and a relatively inexpensive way to set up flexible biopharmaceutical operations. They are especially well suited to all adherent based vaccines and viral vector processes (MDCK, VERO, PERC6, HEK-293), “clean cells” for fermenter cultures and recombinant proteins.
Time to Market
It takes less than two months to convert from labscale to commercial maufacturing with the RC-40.
RC-40 MAKES ROLLER BOTTLES COOL AGAIN
Each frame handles 40 roller bottle processes simultaneously
Who We Are
SaniSure is a global leader in simplifying single-use systems for sterile drug and vaccine manufacturing and other biotech applications. With the combination of industry-leading single-use technology (SUT) companies (Cellon, Silicone Altimex, TBL Performance Plastics, GL Engineering and Sani-Tech West) in to SaniSure, our resources, capabilities, and ability to create value for customers is greater than ever and unmatched in the industry.
Our core manufacturing capabilities include injection molding, injection-stretch blow molding, cleanroom assembly, tubing extrusion, fabrication, needle manufacturing, and other proprietary technologies. With a global footprint of 6 manufacturing sites, we provide an unrivaled level of vertical integration and supply- chain security. Our founding companies have been at the forefront of SUT innovation for decades and have supported many clients through all phases of drug and vaccine development and production.
- ZAE Robert Steichen
- 16, rue Héierchen
- L4940 Bascharage
- Grand Duché du Luxembourg
- 1020 Flynn Road
- Camarillo, CA 93012
TRY OUR RC-40 PROCESSING SYSTEM & PROPRIETARY BOTTLE PACKS IN YOUR FACILITY
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