About This White Paper

Why Pressure Sensor Design Determines Process Reliability

Pressure measurement failures are silent. MEMS-based single-use sensors introduce increasing error as operating pressure rises. At 32 PSI, that error can reach 0.84 PSI or more. In filtration, transfer, and hold steps where TMP accuracy drives product quality decisions, that variability isn’t a calibration issue. It’s a process risk.

This white paper presents a direct comparative evaluation of pressure measurement accuracy using an Ashcroft® pressure transmitter across a 0.5 to 45 PSI range, the typical working window for bioprocessing fluid handling. The data shows a clear difference in performance between aSURE™ Instrument Tees and leading MEMS-based single-use sensor designs.

What’s inside
  • Comparative error performance: aSURE™ Instrument Tees vs. MEMS-based sensors across 0.5 to 45 PSI
  • Root cause analysis of signal drift in embedded electronic sensors
  • Impact on batch-to-batch reproducibility and deviation investigation burden
  • Integration guidance for existing Ashcroft® and standard sanitary instrumentation
  • Upstream and downstream application fit assessment
27× Lower error vs. MEMS sensors at 32 PSI
≤0.03 PSI measurement error — aSURE™ full range
0.5–45 PSI operating range evaluated
Key findings
Error Scales with Pressure in MEMS Systems

MEMS sensors are least accurate precisely where process variability has the greatest consequence, at higher operating pressures.

Signal Drift Degrades Batch Consistency

Voltage instability in embedded electronics introduces variability during filtration, transfer, and control steps.

Stable Data Supports Reproducibility

aSURE™ Instrument Tees deliver NIST-traceable accuracy across the full range, simplifying deviation investigation.

Standard Instrumentation — No Lock-In

Connects to existing Ashcroft® and standard sanitary gauges. No new hardware qualification required.

This resource is written for bioprocess engineers and MSAT teams evaluating pressure measurement technologies in single-use systems, where sensor selection directly affects process control, regulatory compliance, and scale-up confidence.

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Achieving Accurate Pressure Measurement in Bioprocessing
White Paper  /  aSURE™ Instrument Tees  /  PDF
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